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  1. The demand for biobased polymers is increasing steadily worldwide. Microbial hosts for production of their monomeric precursors such as glutarate are developed. To meet the market demand, production hosts have...

    Authors: Carina Prell, Tobias Busche, Christian Rückert, Lea Nolte, Christoph Brandenbusch and Volker F. Wendisch

    Citation: Microbial Cell Factories 2021 20:97

    Content type: Research

    Published on:

  2. Surfactin, a representative biosurfactant of lipopeptide mainly produced by Bacillus subtilis, consists of a cyclic heptapeptide linked to a β-hydroxy fatty acid chain. The functional activity of surfactin is clo...

    Authors: Fangxiang Hu, Weijie Cai, Junzhang Lin, Weidong Wang and Shuang Li

    Citation: Microbial Cell Factories 2021 20:96

    Content type: Research

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  3. The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the need to develop safe and effective vaccines with a top priority....

    Authors: Tong Gao, Yi Ren, Shuangqin Li, Xin Lu and Han Lei

    Citation: Microbial Cell Factories 2021 20:95

    Content type: Research

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  4. Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on th...

    Authors: Neil C. Dalvie, Joseph R. Brady, Laura E. Crowell, Mary Kate Tracey, Andrew M. Biedermann, Kawaljit Kaur, John M. Hickey, D. Lee Kristensen II, Alexandra D. Bonnyman, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Marina Bok, Celina Vega, Tarit K. Mukhopadhyay, Sangeeta B. Joshi, David B. Volkin…

    Citation: Microbial Cell Factories 2021 20:94

    Content type: Research

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  5. Poly(ethylene terephthalate) (PET) is the world’s most abundant polyester plastic, and its ongoing accumulation in nature is causing a global environmental problem. Currently, the main recycling processes u...

    Authors: Sophia A. H. Heyde, Jenny Arnling Bååth, Peter Westh, Morten H. H. Nørholm and Kenneth Jensen

    Citation: Microbial Cell Factories 2021 20:93

    Content type: Research

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  6. Nitric oxide (NO) is a ubiquitous signaling mediator in various physiological processes. However, there are less reports concerning the effects of NO on fungal secondary metabolites. Hypocrellins are effective...

    Authors: Yan Jun Ma, Xin Ping Li, Yue Wang and Jian Wen Wang

    Citation: Microbial Cell Factories 2021 20:92

    Content type: Research

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  7. Protein synthesis is one of the extremely important anabolic pathways in the yeast expression system Pichia pastoris. Codon optimization is a commonly adopted strategy for improved protein expression, although un...

    Authors: Yichun Xu, Kunshan Liu, Yu Han, Yanzi Xing, Yuanxing Zhang, Qiuying Yang and Mian Zhou

    Citation: Microbial Cell Factories 2021 20:91

    Content type: Research

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  8. Currently, the numerous and versatile applications in pharmaceutical and chemical industry make the recombinant production of cytochrome P450 enzymes (CYPs) of great biotechnological interest. Accelerating the...

    Authors: Javier Garrigós-Martínez, Astrid Weninger, José Luis Montesinos-Seguí, Christian Schmid, Francisco Valero, Claudia Rinnofner, Anton Glieder and Xavier Garcia-Ortega

    Citation: Microbial Cell Factories 2021 20:90

    Content type: Research

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  9. SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far. Based on the urgent need fo...

    Authors: Norma A. Valdez-Cruz, Enrique García-Hernández, Clara Espitia, Laura Cobos-Marín, Claudia Altamirano, Carlos G. Bando-Campos, Luis F. Cofas-Vargas, Enrique W. Coronado-Aceves, Ricardo A. González-Hernández, Pablo Hernández-Peralta, Daniel Juárez-López, Paola A. Ortega-Portilla, Sara Restrepo-Pineda, Patricio Zelada-Cordero and Mauricio A. Trujillo-Roldán

    Citation: Microbial Cell Factories 2021 20:88

    Content type: Review

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  10. Trans-4-hydroxy-l-proline is an important amino acid that is widely used in medicinal and industrial applications, particularly as a valuable chiral building block for the organic synthesis of pharmaceuticals. Tr...

    Authors: Zhenyu Zhang, Pengfu Liu, Weike Su, Huawei Zhang, Wenqian Xu and Xiaohe Chu

    Citation: Microbial Cell Factories 2021 20:87

    Content type: Review

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  11. Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR),...

    Authors: Huimin Wang, Junheng Liang, Qianwen Yue, Long Li, Yan Shi, Guosong Chen, Yue-zhong Li, Xiaoying Bian, Youming Zhang, Guoping Zhao and Xiaoming Ding

    Citation: Microbial Cell Factories 2021 20:86

    Content type: Research

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  12. Lactobacillus (Limosilactobacillus) fermentum D12 is an exopolysaccharide (EPS) producing strain whose genome contains a putative eps operon. Whole-genome analysis of D12 was performed to disclose the essential g...

    Authors: Katarina Butorac, Jasna Novak, Barbara Bellich, Lucrecia C. Terán, Martina Banić, Andreja Leboš Pavunc, Slaven Zjalić, Paola Cescutti, Jagoda Šušković and Blaženka Kos

    Citation: Microbial Cell Factories 2021 20:85

    Content type: Research

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  13. Poly-γ-glutamic acid (γ-PGA) and nattokinase (NK) are the main substances produced by Bacillus subtilis natto in solid-state fermentation and have wide application prospects. We found that our strains had higher ...

    Authors: Min Li, Zilong Zhang, Shenwei Li, Zhengan Tian and Xia Ma

    Citation: Microbial Cell Factories 2021 20:83

    Content type: Research

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  14. Trehalose, an intracellular protective agent reported to mediate defense against many stresses, can alleviate high-temperature-induced damage in Pleurotus ostreatus. In this study, the mechanism by which trehalos...

    Authors: Zhi-Yu Yan, Meng-Ran Zhao, Chen-Yang Huang, Li-Jiao Zhang and Jin-Xia Zhang

    Citation: Microbial Cell Factories 2021 20:82

    Content type: Research

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  15. Phosphonates derivatives are in the area of interests because of their unique chemical-physical features. These compounds manifest variety of biological interactions within the sensitive living cells, includin...

    Authors: Monika Serafin-Lewańczuk, Małgorzata Brzezińska-Rodak, Katarzyna Lubiak-Kozłowska, Paulina Majewska, Magdalena Klimek-Ochab, Tomasz K. Olszewski and Ewa Żymańczyk-Duda

    Citation: Microbial Cell Factories 2021 20:81

    Content type: Review

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  16. Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have ...

    Authors: Lanchai Chen, Zhuolin Yi, Yang Fang, Yanling Jin, Kaize He, Yao Xiao, Dong Zhao, Huibo Luo, Hui He, Qun Sun and Hai Zhao

    Citation: Microbial Cell Factories 2021 20:80

    Content type: Research

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  17. Glucosylglycerol (2-O-α-d-glucosyl-sn-glycerol; GG) is a natural osmolyte from bacteria and plants. It has promising applications as cosmetic and food-and-feed ingredient. Due to its natural scarcity, GG must be ...

    Authors: Katharina N. Schwaiger, Monika Cserjan-Puschmann, Gerald Striedner and Bernd Nidetzky

    Citation: Microbial Cell Factories 2021 20:79

    Content type: Research

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  18. Colonization of intestinal microbiota in ruminant during the early life is important to host health, metabolism and immunity. Accumulating evidence revealed the ameliorative effect of milk replacer administrat...

    Authors: Aoyun Li, Yan Yang, Songkang Qin, Shenjin Lv, Taihua Jin, Kun Li, Zhaoqing Han and Yongzhu Li

    Citation: Microbial Cell Factories 2021 20:78

    Content type: Research

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  19. Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacil...

    Authors: Soyon Mann, Myeong Soo Park, Tony V. Johnston, Geun Eog Ji, Keum Taek Hwang and Seockmo Ku

    Citation: Microbial Cell Factories 2021 20:75

    Content type: Research

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  20. Pichia pastoris is a powerful and broadly used host for recombinant protein production (RPP), where past bioprocess performance has often been directed with the methanol regulated AOX1 promoter (PAOX1), and the c...

    Authors: Javier Garrigós-Martínez, Kiira Vuoristo, Miguel Angel Nieto-Taype, Juha Tähtiharju, Jaana Uusitalo, Pauliina Tukiainen, Christian Schmid, Ilya Tolstorukov, Knut Madden, Merja Penttilä, José Luis Montesinos-Seguí, Francisco Valero, Anton Glieder and Xavier Garcia-Ortega

    Citation: Microbial Cell Factories 2021 20:74

    Content type: Research

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  21. Escherichia coli is generally used as model bacteria to define microbial cell factories for many products and to investigate regulation mechanisms. E. coli exhibits phospholipids, lipopolysaccharides, colanic aci...

    Authors: Jianli Wang, Wenjian Ma and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2021 20:73

    Content type: Review

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  22. The large-scale application of organic pollutants (OPs) has contaminated the air, soil, and water. Persistent OPs enter the food supply chain and create several hazardous effects on living systems. Thus, there...

    Authors: Pankaj Bhatt, Amit Verma, Saurabh Gangola, Geeta Bhandari and Shaohua Chen

    Citation: Microbial Cell Factories 2021 20:72

    Content type: Review

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  23. The spore-forming lactic acid bacterium Bacillus coagulans MA-13 has been isolated from canned beans manufacturing and successfully employed for the sustainable production of lactic acid from lignocellulosic biom...

    Authors: Martina Aulitto, Andrea Strazzulli, Ferdinando Sansone, Flora Cozzolino, Maria Monti, Marco Moracci, Gabriella Fiorentino, Danila Limauro, Simonetta Bartolucci and Patrizia Contursi

    Citation: Microbial Cell Factories 2021 20:71

    Content type: Research

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  24. Ascomycin is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. As a secondary metabolite, the production of ascomycin is often limited by the shortage of precursors during th...

    Authors: Pan Wang, Ying Yin, Xin Wang and Jianping Wen

    Citation: Microbial Cell Factories 2021 20:70

    Content type: Research

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  25. Myriocin is a natural product with antifungal activity and is derived from Bacillus amyloliquefaciens LZN01. Our previous work demonstrated that myriocin can inhibit the growth of Fusarium oxysporum f. sp. niveum

    Authors: Hengxu Wang, Zhigang Wang, Weihui Xu and Kexin Wang

    Citation: Microbial Cell Factories 2021 20:69

    Content type: Research

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  26. Most patients with acute myeloid leukemia (AML) remain uncurable and require novel therapeutic methods. Gain-of-function FMS-like tyrosine kinase 3 (FLT3) mutations are present in 30–40% of AML patients and se...

    Authors: Dengyang Zhang, Yao Guo, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Junbin Huang, Chun Chen, Hongman Xue, Xiaojun Xu, Yihang Pan, Ningning Li, Chengming Zhu, Zhizhuang Joe Zhao, Jian Yu and Yun Chen

    Citation: Microbial Cell Factories 2021 20:67

    Content type: Research

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  27. The polyene macrocyclic compound amphotericin B (AmB) is an important antifungal antibiotic for the clinical treatment of invasive fungal infections. To rationally guide the improvement of AmB production in th...

    Authors: Bo Zhang, Yu Chen, Sheng-Xian Jiang, Xue Cai, Kai Huang, Zhi-Qiang Liu and Yu-Guo Zheng

    Citation: Microbial Cell Factories 2021 20:66

    Content type: Research

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  28. The C-3′,4′-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3′-phosphotransferase (APH(3′)) in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation st...

    Authors: Shaotong Zhou, Xiaotang Chen, Xianpu Ni, Yu Liu, Hui Zhang, Min Dong and Huanzhang Xia

    Citation: Microbial Cell Factories 2021 20:65

    Content type: Research

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  29. Saccharomyces cerevisiae is a well-known popular model system for basic biological studies and serves as a host organism for the heterologous production of commercially interesting small molecules and proteins. T...

    Authors: Kanhaiya Kumar, Vishwesh Venkatraman and Per Bruheim

    Citation: Microbial Cell Factories 2021 20:64

    Content type: Research

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  30. The alcohol 2,3-butanediol (2,3-BDO) is an important chemical and an Escherichia coli producer strain was recently engineered for bio-based production of 2,3-BDO. However, further improvements are required for re...

    Authors: Simon Boecker, Björn-Johannes Harder, Regina Kutscha, Stefan Pflügl and Steffen Klamt

    Citation: Microbial Cell Factories 2021 20:63

    Content type: Research

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  31. Valuable polysaccharides are usually produced using wild-type or metabolically-engineered host microbial strains through fermentation. These hosts act as cell factories that convert carbohydrates, such as mono...

    Authors: Zi-Xu Liu, Si-Ling Huang, Jin Hou, Xue-Ping Guo, Feng-Shan Wang and Ju-Zheng Sheng

    Citation: Microbial Cell Factories 2021 20:62

    Content type: Review

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  32. The chloroacetamide herbicides pretilachlor is an emerging pollutant. Due to the large amount of use, its presence in the environment threatens human health. However, the molecular mechanism of pretilachlor de...

    Authors: Hong-ming Liu, Meng Yuan, Ai-min Liu, Lei Ren, Guo-ping Zhu and Li-na Sun

    Citation: Microbial Cell Factories 2021 20:61

    Content type: Research

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  33. d-Allulose is an ultra-low calorie sugar of multifarious health benefits, including anti-diabetic and anti-obesity potential. d-Allulose 3-epimerase family enzymes catalyze biosynthesis of d-allulose via epimeriz...

    Authors: Satya Narayan Patel, Girija Kaushal and Sudhir P. Singh

    Citation: Microbial Cell Factories 2021 20:60

    Content type: Research

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  34. Oleaginous filamentous fungi can accumulate large amount of cellular lipids and potentially serve as a major source of oleochemicals for food, feed, chemical, pharmaceutical, and transport industries. Transest...

    Authors: Anne Marie Langseter, Simona Dzurendova, Volha Shapaval, Achim Kohler, Dag Ekeberg and Boris Zimmermann

    Citation: Microbial Cell Factories 2021 20:59

    Content type: Research

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  35. Betaine, an osmoprotective compatible solute, has been used to improve l-threonine production in engineered Escherichia coli l-threonine producer. Betaine supplementation upregulates the expression of zwf encodin...

    Authors: Shuaiwen Wang, Yu Fang, Zhen Wang, Shuyan Zhang, Liangjia Wang, Yong Guo and Xiaoyuan Wang

    Citation: Microbial Cell Factories 2021 20:58

    Content type: Research

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  36. Retention of agricultural bio-mass residues without proper treatment could affect the subsequent plant growth. In the present investigation, the co-cultivation of genetically engineered T. asperellum and B. amylo...

    Authors: Valliappan Karuppiah, Lu Zhixiang, Hongyi Liu, Murugappan Vallikkannu and Jie Chen

    Citation: Microbial Cell Factories 2021 20:57

    Content type: Research

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  37. Antibiotic-resistant bacteria have emerged as a serious problem; bacteriophages have, therefore, been proposed as a therapeutic alternative to antibiotics. Several authorities, such as pharmacopeia, FDA, have ...

    Authors: Sang Guen Kim, Jun Kwon, Sib Sankar Giri, Saekil Yun, Hyoun Joong Kim, Sang Wha Kim, Jung Woo Kang, Sung Bin Lee, Won Joon Jung and Se Chang Park

    Citation: Microbial Cell Factories 2021 20:56

    Content type: Research

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  38. The accelerating energy demands of the increasing global population and industrialization has become a matter of great concern all over the globe. In the present scenario, the world is witnessing a considerabl...

    Authors: Praveen C. Ramamurthy, Simranjeet Singh, Dhriti Kapoor, Parul Parihar, Jastin Samuel, Ram Prasad, Alok Kumar and Joginder Singh

    Citation: Microbial Cell Factories 2021 20:55

    Content type: Review

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  39. Linalool, an acyclic monoterpene alcohol, is extensively used in the flavor and fragrance industries and exists as two enantiomers, (S)- and (R)-linalool, which have different odors and biological properties. Lin...

    Authors: Nobuhisa Nitta, Yoshinori Tajima, Yoko Yamamoto, Mika Moriya, Akiko Matsudaira, Yasushi Hoshino, Yousuke Nishio and Yoshihiro Usuda

    Citation: Microbial Cell Factories 2021 20:54

    Content type: Research

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  40. The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microb...

    Authors: Xin Yuan, Ruimin Chen, Kenneth L. McCormick, Ying Zhang, Xiangquan Lin and Xiaohong Yang

    Citation: Microbial Cell Factories 2021 20:53

    Content type: Research

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  41. Mucor circinelloides WJ11 is a high-lipid producing strain and an excellent producer of γ-linolenic acid (GLA) which is crucial for human health. We have previously identified genes that encode for AMP-activated...

    Authors: Shaista Nosheen, Tahira Naz, Junhuan Yang, Syed Ammar Hussain, Abu Bakr Ahmad Fazili, Yusuf Nazir, Shaoqi Li, Hassan Mohamed, Wu Yang, Kiren Mustafa and Yuanda Song

    Citation: Microbial Cell Factories 2021 20:52

    Content type: Research

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  42. Substrate-limited fed-batch conditions have the favorable effect of preventing overflow metabolism, catabolite repression, oxygen limitation or inhibition caused by elevated substrate or osmotic concentrations...

    Authors: Tobias Habicher, Tobias Klein, Jacqueline Becker, Andreas Daub and Jochen Büchs

    Citation: Microbial Cell Factories 2021 20:51

    Content type: Research

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  43. Xylitol is a five-carbon sugar alcohol that has numerous beneficial health properties. It has almost the same sweetness as sucrose but has lower energy value compared to the sucrose. Metabolism of xylitol is i...

    Authors: Tai Man Louie, Kailin Louie, Samuel DenHartog, Sridhar Gopishetty, Mani Subramanian, Mark Arnold and Shuvendu Das

    Citation: Microbial Cell Factories 2021 20:50

    Content type: Research

    Published on:

  44. Humic substances (HS) form the largest proportion among all the constituents of soil organic matter and are a key component of the terrestrial ecosystem. HS plays a multifunctional role in the environment by c...

    Authors: Iniyakumar Muniraj, Syed Shameer, Priyadharshini Ramachandran and Sivakumar Uthandi

    Citation: Microbial Cell Factories 2021 20:48

    Content type: Research

    Published on:

  45. With the long-term goal of developing an ultra-sensitive microcantilever-based biosensor for versatile biomarker detection, new controlled bioreceptor-analytes systems are being explored to overcome the disadv...

    Authors: Nurul Akmal Che Lah, Robert Gray and Sonia Trigueros

    Citation: Microbial Cell Factories 2021 20:46

    Content type: Research

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