Average titer (g l− 1) | ||||||||
---|---|---|---|---|---|---|---|---|
Nanobody valency | ||||||||
System | Strain | Average titer (g l− 1) | mono | bi | tri | tetra | penta | hexa |
Methanol-based | NRRL Y-11430 | 1.4 (N = 54) | 2.7 (N = 13) | 1.8 (N = 4) | 0.8 (N = 18) | 1.1 (N = 17) | 0.8 (N = 2) | -a |
NRRL Y-11430 + RPP0 + KAR2 + PDI + HAC1 | 3.1 (N = 849) | 2.7 (N = 314) | 3.2 (N = 82) | 3.2 (N = 148) | 3.4 (N = 172) | 3 (N = 102) | 4.1 (N = 31) | |
Methanol-free | NRRL Y-11430 | 0.6 (N = 16) | - | 0.4 (N = 2) | - | 0.5 (N = 11) | 1.4 (N = 3) | - |
NRRL Y-11430 + HAC1 | 3.7 (N = 156) | 3.4 (N = 93) | 4.3 (N = 12) | 4.5 (N = 12) | 3.7 (N = 30) | 4.6 (N = 8) | 3.6 (N = 1) |