Table 1 Structural information of Enzymes targeted by amino acid feedback inhibition retrieved from UniProt database
From: Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Organism | EC number | AA synthesis pathway | AA end product inhibition | Cross-reference (PDB) | 3D-structure | Reference |
|---|---|---|---|---|---|---|
Mycobacterium tuberculosis | 2.3.1.1 | Arginine | Arg | 5YGE;5YO2;6ADD; |
| |
Thermotoga maritima | 2.7.2.8 | Arginine | Arg | 2BTY; | ||
Saccharomyces cerevisiae | 1.2.1.38; 2.7.2.8 | Arginine | Arg | 3ZZF;3ZZG;3ZZH;3ZZI;4AB7; | ||
Escherichia coli | 2.3.1.30 | Cysteine | Cys | 1T3D; |
| [48] |
Salmonella typhimurium | 2.3.1.30 | Cysteine | Cys | 4LI3;4NU8;4ZU1;4ZU6;5DBE;6AIF; | ||
Methanothermobacter thermautotrophicus | 2.4.2.17 | Histidine | His | 2VD3; |
| |
Mycobacterium tuberculosis | 2.4.2.17 | Histidine | His | 1NH7;1NH8;5LHT;5LHU;5U99; | ||
Campylobacter jejuni | 2.4.2.17 | Histidine | His | 4YB5;4YB6;4YB7;5UB9;5UBG;5UBH;5UBI; | ||
Escherichia coli | 2.4.2.17 | Histidine | His | 1H3D;1Q1K; | ||
Escherichia coli | 4.3.1.19 | Isoleucine | Ile | 1TDJ; |
| [52] |
Leptospira interrogans | 2.3.1.182 | Isoleucine | Ile | 3BLE;3BLF;3BLI;3F6G;3F6H; | ||
Escherichia coli | 2.2.1.6 | Isoleucine | Val | 2F1F; |
| [53] |
Saccharomyces cerevisiae | 2.2.1.6 | Isoleucine | Val | 1JSC;1N0H;1T9A;1T9B;1T9C;1T9D;5FEM;5IMS;5WKC;6BD3;6BD9;6U9D; | ||
Sulfolobus acidocaldarius | 2.3.3.14 | Lysine | Lys | 6KTQ; | AKIII | [54] |
Thermus thermophilus | 2.3.3.14 | Lysine | Lys | 2ZTJ;2ZTK;2ZYF;3A9I; | ||
Escherichia coli | 2.7.2.4 | Lysine | Lys | 2J0W;2J0X; | ||
Corynebacterium glutamicum | 2.7.2.4 | Lysine | Lys | 2DTJ;3AAW;3AB2;3AB4; | ||
Escherichia coli | 2.7.2.4; 1.1.1.3 | Lysine | Thr | 6MX1; | AK | [55] |
Mycobacterium tuberculosis | 2.7.2.4 | Lysine | Thr | 3S1T;4GO5;4GO7; | ||
Thermus thermophilus | 2.7.2.4 | Lysine | Thr | 2DT9;2ZHO; | ||
Escherichia coli | 1.2.1.11 | Lysine | Cys | 1BRM;1GL3;1T4B;1T4D; |
| [56] |
Agrobacterium fabrum | 4.3.3.7 | Lysine | Lys | 4I7U;4I7V;4I7W; |
| [57] |
Escherichia coli | 4.3.3.7 | Lysine | Lys | 1DHP;1S5T;1S5V;1S5W;1YXC;1YXD;2A6L;2A6N;2ATS;2OJP;2PUR;3C0J;3DEN;3DU0;3I7Q;3I7R;3I7S;4EOU;5T25;5T26 | ||
Mycobacterium tuberculosis | 4.3.3.7 | Lysine | Lys | 1XXX;3L21;5J5D; | ||
Neisseria meningitidis serogroup B | 4.3.3.7 | Lysine | Lys | 3FLU; | ||
Rhizobium meliloti | 4.3.3.7 | Lysine | Lys | 2VC6; | ||
Escherichia coli | 4.4.1.13; 4.4.1.28 | Methionine | Cys | 1CL1;1CL2;2FQ6;2GQN;4ITG;4ITX; | CBL | [58] |
Thermus thermophilus | 2.5.1.- | Methionine | Met | 2CTZ; | ||
Rhodococcus sp. | 1.4.1.20 | Phenylalanine | Phe | 1BW9;1BXG;1C1D;1C1X; |
| [59] |
Escherichia coli | 5.4.99.5; 4.2.1.51 | Phenylalanine | Phe | 1ECM;5VHT; | ||
Escherichia coli | 2.7.2.11 | Proline | Pro | 2J5T;2J5V;2W21; |
| [60] |
Escherichia coli | 1.1.1.95; 1.1.1.399 | Serine | Ser | 1PSD;1SC6;1YBA;2P9C;2P9E;2P9G;2PA3; |
| [61] |
Arabidopsis thaliana | 2.6.1.52 | Serine | Cys | 6CZX;6CZY;6CZZ; | PSAT1 | [62] |
Mycobacterium tuberculosis | 4.1.3.27 | Tryptophan | Trp | 5CWA; | AS | [63] |
Mycolicibacterium smegmatis | 4.1.3.27 | Tryptophan | Trp | 7BVD; | ||
Saccharolobus solfataricus | 4.1.3.27 | Tryptophan | Trp | 1QDL; | ||
Salmonella typhimurium | 4.1.3.27 | Tryptophan | Trp | 1I1Q; | ||
Serratia marcescens | 4.1.3.27 | Tryptophan | Trp | 1I7Q;1I7S; | ||
Salmonella typhimurium | 4.1.3.27; 2.4.2.18 | Tryptophan | Trp | 1I1Q; |
