Table 2 Characteristic features of NAGK (3D-crystal structure) from various organisms
From: Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Enzyme | Structural composition | Key structural features | 3D-view of structure (cartoon representation) | Reference |
|---|---|---|---|---|
NAGK (Yeast) | Tetramer | Central structure is a flat tetramer formed by two dimers of AAK domains Bound arginine and NAG |
| [91] |
NAGK (E.coli) | Homodimer | Each subunit comprised of two lobes (i.e. C-lobe binds ADP moiety of ATP and N-lobe forms inter subunit surface Arginine free |
| |
NAGK (T. maritima) | Hexamer | Formed by linking three E. coli NAGK-like homodimers through the interlacing of an N-terminal mobile kinked a-helix Arginine is bound in each subunit flanking the interdimeric junction, in a site formed between the N helix and the C lobe of the subunit |
| [47] |
NAGK (P. aurogenosa) | Hexamer (Ring-like) | Arginine free Bound NAG and ADP-Mg |
| |
NAGK (C. crenatum | Swiss model hexamer (Ring-like) | Arginine binding domain comprised of Glu19, His26, Arg209 and His268 Glu19 at entrance of binding site is key amino acid |
| [93] |
