Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Mota, Marta N.; Matos, Madalena; Bahri, Nada; Sá-Correia, Isabel

doi:10.1186/s12934-024-02309-0

Table 2 Genes involved in vacuolar acidification

From: Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Gene/ORF	Description of the encoded protein function	Susceptibility
Gene/ORF	Description of the encoded protein function	C2	C4	C8
DBF2	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis	+	+	+
MEH1	Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest	0	0	+
PFK2	Beta subunit of heterooctameric phosphofructokinase, involved in glycolysis	+ +	+ +	+ +
RAV2	Subunit of RAVE complex	0	+	+
RRG1	No demonstrated function but Rrg1p may be required for vacuolar acidification, efficient 5′ processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance	0	+	+
VMA1	Subunit A of the V1 peripheral membrane domain of V-ATPase	+	+	+
VMA10	Subunit G of the V1 peripheral membrane domain of V-ATPase. Vma10p is involved in vacuolar acidification	+ +	+	+
VMA11	Vacuolar ATPase V0 domain subunit c′. Vma11p is involved in proton transport activity	+	+	+
VMA13	Subunit H of the V1 peripheral membrane domain of V-ATPase. Vma13p serves as an activator or a structural stabilizer of the V-ATPase	0	0	+
VMA16	Subunit c′′ of the vacuolar ATPase	+	+	+
VMA2	Subunit B of V1 peripheral membrane domain of vacuolar H⁺-ATPase	+	+	+
VMA3	Proteolipid subunit c of the V0 domain of vacuolar H⁺ -ATPase. Vma3p is required for vacuolar acidification	+	+	+
VMA5	Subunit C of the V1 peripheral membrane domain of V-ATPase. Vma5p is required for the V1 domain to assemble onto the vacuolar membrane	+	+	+
VMA7	Subunit F of the V1 peripheral membrane domain of V-ATPase. Vma7p is required for the V1 domain to assemble onto the vacuolar membrane;	+	+	+
VPH1	Subunit a of the vacuolar-ATPase V0 domain located in vacuolar V-ATPase complexes	+	+	+
VPH2	Integral membrane protein required for V-ATPase function. Vph2p is involved in the assembly of the V-ATPase	+	+	+
VPS3	Component of CORVET membrane tethering complex. Vps3p is involvedin the acidification of the vacuolar lumen and in the assembly of the vacuolar H⁺-ATPase	+	+	+

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ISSN: 1475-2859

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