Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Mota, Marta N.; Matos, Madalena; Bahri, Nada; Sá-Correia, Isabel

doi:10.1186/s12934-024-02309-0

Table 5 Genes involved in mitochondrial genome maintenance

From: Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Gene/ ORF	Description of the encoded protein function	Susceptibility
Gene/ ORF	Description of the encoded protein function	C2	C4	C8
EXO5	Mitochondrial 5′-3′ exonuclease and sliding exonuclease required for mitochondrial genome maintenance	0	0	+
ILM1	No demonstrated function but Ilm1p may be involved in mitochondrial DNA maintenance	+	+	+
IRC3	Double-stranded DNA-dependent helicase of the DExH/D-box family, also containing double-stranded DNA translocase activity. Irc3p is responsible for maintenance of the mitochondrial (mt) genome	0	+	+
MDJ1	Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity. Mdj1p participates in protein folding/refolding in the mitochodrial matrix	+ +	+ +	+ +
MDM12	Mitochondrial outer membrane protein, ERMES complex subunit. Mdm12p is required for transmission of mitochondria to daughter cells and mitophagy	0	0	+
MGM1	Mitochondrial GTPase, present in a complex with Ugo1p and Fzo1p. Mgm1p is required for mitochondrial morphology, fusion, and genome maintenance	+	+	+
MHR1	Mitochondrial ribosomal protein of the large subunit. Mhr1p is involved in homologous recombination in mitochondria; it is required for recombination-dependent mtDNA partitioning; and stimulation of mitochondrial DNA replication in response to oxidative stress	0	+	+
MIP1	Mitochondrial DNA polymerase gamma	0	0	+
MRPL51	Mitochondrial ribosomal protein of the large subunit. Mrpl51p is required for mitochondrial genome integrity, respiratory growth, and mitochondrial redox homeostasis	+	+	+
RRG8	No demonstrated function but Rrg8p may be required for efficient 5′ processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance	0	0	+
RRG9	No demonstrated function but rrg9Δ lacks mitochondrial DNA and cannot grow on glycerol	0	0	+

The table includes the list of genes involved in mitochondrial genome maintenance, identified in this study as determinants of yeast tolerance to acetic acid (C2), butyric acid (C4) or octanoic acid (C8). Table elaborated as described in Table 2

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ISSN: 1475-2859

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