Table 7 Genes involved in cell wall synthesis and assembly
Gene/ORF | Description of the encoded protein function | Susceptibility | ||
|---|---|---|---|---|
C2 | C4 | C8 | ||
CHS1 | Chitin synthase I required for repairing the chitin septum during cytokinesis |  +  | 0 | 0 |
CTS1 | Endochitinase required for cell separation after mitosis; transcriptional activation mediated by transcription factor Ace2p | 0 |  +  | 0 |
FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p. Fks1p binds to regulatory subunit Rho1p and is involved in cell wall synthesis and maintenance, localizing to sites of cell wall remodeling |  +  |  +  |  +  |
GAS1 | Beta-1,3-glucanosyltransferase required for cell wall assembly. Gas1p interaction with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate a role in DNA damage response and cell cycle regulation |  +  |  +  |  +  |
HOC1 | Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis |  +  | 0 |  +  |
KRE6 | Glucosyl hydrolase required for beta-1,6-glucan biosynthesis | 0 | 0 |  +  |
MNN10 | Subunit of a Golgi mannosyltransferase complex that mediates elongation of the polysaccharide mannan backbone |  +  +  |  +  +  |  +  +  |
MNN2 | Alpha-1,2-mannosyltransferase responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides | 0 | 0 |  +  |
MNN9 | Subunit of Golgi mannosyltransferase complex that mediates elongation of the polysaccharide mannan backbone. Separately forms a complex with Van1p that is also involved in backbone elongation |  +  +  |  +  +  |  +  +  |
OCH1 | Mannosyltransferase of the cis-Golgi apparatus involved in initiating the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins |  +  +  |  +  +  |  +  +  |
YGP1 | Cell wall-related secretory glycoprotein that is induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase | 0 | 0 |  +  |