Gene/ORF | Description of the encoded protein function | Susceptibility | ||
---|---|---|---|---|
C2 | C4 | C8 | ||
CDC50 | Endosomal protein that interacts with phospholipid flippase Drs2p |  +  +  | 0 | 0 |
CHO1 | Phosphatidylserine synthase required for phospholipid biosynthesis | 0 |  +  |  +  |
CSG2 | Endoplasmic reticulum membrane protein required for mannosylation of inositolphosphorylceramide Csg2p concentration increases in response to DNA replication stress | 0 |  +  |  +  +  |
DNF2 | Aminophospholipid translocase (flippase) involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization | 0 | 0 |  +  +  |
DRS2 | Trans-golgi network aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles and contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone |  +  |  +  |  +  |
ELO2 | Fatty acid elongase that is involved in sphingolipid biosynthesis and acts on fatty acids of up to 24 carbons in length |  +  |  +  |  +  +  |
ELO3 | Elongase involved in fatty acid and sphingolipid biosynthesis, synthesizing very long chain 20–26-carbon fatty acids from C18-CoA primers. Elo3p is also involved in regulation of sphingolipid biosynthesis |  +  | 0 |  +  |
ERG2 | C-8 sterol isomerase that catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis. ERG2 expression is down-regulated when ergosterol is in excess |  +  +  |  +  +  |  +  +  |
ERG24 | C-14 sterol reductase that acts in ergosterol biosynthesis |  +  |  +  |  +  |
ERG28 | Endoplasmic reticulum membrane protein that possibly facilitates protein–protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p |  +  +  |  +  +  |  +  +  |
ERG4 | C-24(28) sterol reductase that catalyzes the final step in ergosterol biosynthesis |  +  +  |  +  +  | 0 |
ERG5 | C-22 sterol desaturase. Erg5p is a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis |  +  | 0 |  +  |
FAA3 | Long chain fatty acyl-CoA synthetase that activates imported fatty acids with a preference for C16:0-C18:0 chain lengths | 0 | 0 |  +  |
GEP4 | Mitochondrial phosphatidylglycerophosphatase that dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis |  +  |  +  |  +  |
LAF1 | Sterol-binding beta-propeller protein essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum | 0 | 0 |  +  |
LEM3 | Membrane protein of the plasma membrane and ER that interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p. Lem3p is involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane |  +  | 0 | 0 |
LOA1 | Lysophosphatidic acid acyltransferase involved in triacelglyceride homeostasis and lipid droplet formation |  +  |  +  |  +  |
OPI3 | Methylene-fatty-acyl-phospholipid synthase that catalyzes the last two steps in phosphatidylcholine biosynthesis. Opi3p is also known as phospholipid methyltransferase |  +  | 0 |  +  |
PSD1 | Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine | 0 | 0 |  +  |
SAC1 | Phosphatidylinositol phosphate phosphatase with a role in protein trafficking, processing, secretion, and cell wall maintenance. Sac1p also regulates sphingolipid biosynthesis |  +  +  |  +  +  | 0 |
SKN1 | Protein involved in sphingolipid biosynthesis | 0 | 0 |  +  |
SPF1 | P-type ATPase required to maintain normal lipid and sterol composition of intracellular compartments. Spf1p is also involved in Ca2+ homeostasis | 0 | 0 |  +  +  |
SUR1 | Mannosylinositol phosphorylceramide synthase catalytic subunit that forms a complex with regulatory subunit Csg2p | 0 | 0 |  +  +  |
SUR2 | Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosynthesis |  +  | 0 | 0 |