Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Table 9 Genes encoding membrane transporters

Gene/ORF	Description of the encoded protein function	Susceptibility
Gene/ORF	Description of the encoded protein function	C2	C4	C8
BAP2	High-affinity leucine permease. Bap2p is also involved in the uptake of leucine, isoleucine and valine	+	+	0
GUP1	Plasma membrane protein involved in remodeling GPI anchors. Gup1p is proposed to be involved in glycerol transport	0	+	+
OXA1	Mitochondrial inner membrane insertase that also acts as a voltage-gated ion channel	+	+	+
PDR12	Plasma membrane ATP-binding cassette (ABC) transporter that is a weak-acid-inducible multidrug transporter required for weak organic acid resistance	0	+ +	+
PET8	S-adenosylmethionine transporter of the mitochondrial inner membrane	0	+	+
PMR1	High affinity Ca²⁺/Mn²⁺ P-type ATPase required for Ca²⁺ and Mn²⁺ transport into Golgi	+	+	+
POR1	Mitochondrial porin (voltage-dependent anion channel)	0	+	+
PRM6	Potassium transporter that mediates K⁺ influx and activates the high-affinity Ca²⁺ influx system	0	+	0
TAT1	Amino acid transporter for valine, leucine, isoleucine, and tyrosine with low-affinity for tryptophan and histidine	0	0	+
TRK1	Component of the Trk1p-Trk2p potassium transport system. Trk1p is a high affinity potassium transporter	+	+	+

The table includes the list of genes, encoding membrane transporters, identified in this study as determinants of yeast tolerance to acetic acid (C2), butyric acid (C4) or octanoic acid (C8). Table elaborated as described in Table 2

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