Skip to main content
Fig. 7 | Microbial Cell Factories

Fig. 7

From: The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

Fig. 7

Possible mechanism of rLO action in Jukart cells. l-lysine is an essential amino acid for Jurkat cell proliferation. The degradation of l-lysine by rLO promotes the inhibition of cell proliferation by decreasing the expression of genes from the JNK and p38 pathways. Furthermore, the absence of l-lysine leads to an increase in ROS and decreases in OCR and PGC-1α expression

Back to article page

Microbial Cell Factories

ISSN: 1475-2859

Contact us