Fig. 7

Graphical representation of the process model. The dark blue ovals indicate probability distributions for a parameter while squares are deterministic combinations of parameters. The empty boxes surrounding groups of parameters indicate the dimensionality of the resulting distributions, where column_id refers to the eight columns in the microtiter plate of the assay and kinetic_id to the unique combination of well and run. Light blue boxes indicate data that can be experimentally observed. The KPI used for ranking is the rate constant of each variant, \({k}_{{\text{variant}}}\) (center right). The two parameters below, \({k}_{{\text{mean}}}\) and \({k}_{{\text{std}}}\) , are hyperpriors that describe the expectation for mean and variance of kinetic rate constants for the whole CatIB library