Skip to main content

Table 4 Matrix and responses of the CCD for the significant factors affecting Taxol production by A. niger

From: Production and bioprocessing of Taxol from Aspergillus niger, an endophyte of Encephalartos whitelockii, with a plausible biosynthetic stability: antiproliferative activity and cell cycle analysis

 

Maltose (g/L)

Lactose (g/L)

Fluconazole (g/L)

Methyl jasmonate (g/L)

Ammonium sulfate (g/L)

Taxol yield (µg/L)

1

2

8

0.1

0.2

2

152

2

1

4

0.5

0.1

5

82.2

3

2

2

0.5

0.1

3

110.2

4

1

8

1

0.4

4

162.2

5

8

12

4

0.4

1

93.2

6

2

8

2

0.6

2

213.8

7

4

4

2

0.6

3

279.8

8

8

8

2

0.4

2

130.1

9

2

12

2

0.2

4

93.4

10

4

4

4

0.2

3

84.1

11

8

4

4

0.4

2

120.1

12

1

4

4

0.8

4

132.1

13

8

8

2

0.8

5

149.7

14

4

2

2

0.1

5

210.1

15

1

2

4

0.1

1

135.9

16

4

2

4

0.6

1

230.1

17

4

8

2

0.8

2

161.6

18

4

2

0.5

0.2

2

141.1

19

8

4

0.5

0.6

4

102.6

20

1

4

0.5

0.6

3

120.8

21

12

4

0.1

0.8

2

120.2

22

8

4

0.1

0.6

4

160.8

23

4

8

2

0.4

5

164.9

24

4

1

2

0.6

4

126.7

25

12

8

4

0.8

5

137.7

26

12

12

2

0.1

3

87.9

27

12

12

4

0.1

3

210.3

28

8

1

4

0.1

3

203.9

29

8

12

4

0.2

4

128.9

30

4

1

4

0.2

4

89.0

31

4

8

2

0.6

1

84.9