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Fig. 3 | Microbial Cell Factories

Fig. 3

From: LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S. aureus biofilms

Fig. 3

Antimicrobial activity of endolysin LysSYL and phage SYL. A Schematic diagram showing the procedure of host range determination assay. B CFU reduction assay for testing lytic activity of LysSYL against MRSA (XN108, USA300, and N315), MSSA (25923 and Newman), P. aeruginosa (PAO1 and PA1), E. coli (DH5α and O157), and A. baumannii (AB2 and 19606). The experiment was repeated three times. Data were presented as mean ± SD. Significance was calculated by two-way ANOVA between LysSYL treatment and PBS control, ns representing no significance, and *** P < 0.001. C Comparison of lytic spectrum of the phage SYL and endolysin LysSYL. Sequence types (STs) and resistance phenotypes of S. aureus strains were presented. Lytic activity was gradually divided into four grades (+++, ++, +, and −) with phenotypes and log10 unit reductions as indicated.

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Microbial Cell Factories

ISSN: 1475-2859

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