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Fig. 4 | Microbial Cell Factories

Fig. 4

From: Combinatorial metabolic engineering of Bacillus subtilis enables the efficient biosynthesis of isoquercitrin from quercetin

Fig. 4

Reducing the deglycosylation of isoquercitrin and enhancing the glycosylation of quercetin to improve glycosides accumulation. (A) The deglycosylation of isoquercitrin and the glycosylation of quercetin; (B) The biomass of glucosidases deletion in B. subtilis recombinants BSCG (initial host), BS221G (control), BS300G (ΔbglA), BS301G (ΔbglH), BS302G (ΔbglC), BS303G (ΔbglAΔbglC), BS304G (ΔbglCΔbglH), BS305G (ΔbglAΔbglH), BS306G (ΔbglAΔbglCΔbglH); (C) Changes of isoquercitrin titer by deleting glucosidases; (D) The concentrations of intracellular UDP-Glc in glucosidase disruption strains; (E) Changes of glucosidases activity by glucosidases disruption

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Microbial Cell Factories

ISSN: 1475-2859

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