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  1. 9α-hydroxyandrost-4-ene-3,17-dione (9-OHAD) is a significant intermediate for the synthesis of glucocorticoid drugs. However, in the process of phytosterol biotransformation to manufacture 9-OHAD, product degr...

    Authors: Xiangcen Liu, Jingxian Zhang, Chenyang Yuan, Guilin Du, Suwan Han, Jiping Shi, Junsong Sun and Baoguo Zhang
    Citation: Microbial Cell Factories 2023 22:53
    Content type: Research Published on:

  2. Thraustochytrids accumulate lipids with a high content of docosahexaenoic acid (DHA). Although their growth and DHA content are significantly affected by the dissolved oxygen (DO) supply, the role of DO on the...

    Authors: Lu Liu, Xingyu Zhu, Huike Ye, Yingying Wen, Biswarup Sen and Guangyi Wang
    Citation: Microbial Cell Factories 2023 22:52
    Content type: Research Published on:

  3. ε-Poly-L-lysine (ε-PL) is a natural and safe food preservative that is mainly produced by filamentous and aerobic bacteria Streptomyces albulus. During ε-PL biosynthesis, a large amount of ATP is used for the pol...

    Authors: Hao Yang, Daojun Zhu, Lang Kai, Liang Wang, Hongjian Zhang, Jianhua Zhang and Xusheng Chen
    Citation: Microbial Cell Factories 2023 22:51
    Content type: Research Published on:

  4. The lipopeptide herbicolin A (HA) secreted by the biocontrol agent Pantoea agglomerans ZJU23 is a promising antifungal drug to combat fungal pathogens by targeting lipid rafts, both in agricultural and clinical s...

    Authors: Hongkai Wang, Yaqi Zhou, Sunde Xu, Boyan Zhang, Tomislav Cernava, Zhonghua Ma and Yun Chen
    Citation: Microbial Cell Factories 2023 22:50
    Content type: Research Published on:

  6. Improving the resistance of Saccharomyces cerevisiae to vanillin, derived from lignin, will benefit the design of robust cell factories for lignocellulosic biorefining. The transcription factor Yrr1p mediates S. ...

    Authors: Weiquan Zhao, Xinning Wang, Bolun Yang, Ying Wang, Zailu Li and Xiaoming Bao
    Citation: Microbial Cell Factories 2023 22:48
    Content type: Research Published on:

  7. Microbially produced bioplastics are specially promising materials since they can be naturally synthesized and degraded, making its end-of-life management more amenable to the environment. A prominent example ...

    Authors: Manuel S. Godoy, Santiago R. de Miguel and M. Auxiliadora Prieto
    Citation: Microbial Cell Factories 2023 22:47
    Content type: Research Published on:

  8. Resveratrol is a commercially available stilbenoid widely used as dietary supplements, functional food ingredients, and cosmetic ingredients due to its diverse physiological activities. The production of resve...

    Authors: Lijun Meng, Mengxue Diao, Qingyan Wang, Longyun Peng, Jianxiu Li and Nengzhong Xie
    Citation: Microbial Cell Factories 2023 22:46
    Content type: Research Published on:

  9. Exopolysaccharides (EPS) secreted by beneficial lactobacilli exert a plethora of positive activities, but little is known about their effects on biofilms of opportunistic vaginal pathogens and especially on bi...

    Authors: Barbara Giordani, Marina Naldi, Vanessa Croatti, Carola Parolin, Ülfet Erdoğan, Manuela Bartolini and Beatrice Vitali
    Citation: Microbial Cell Factories 2023 22:45
    Content type: Research Published on:

  10. Micafungin is an echinocandin-type antifungal agent used for the clinical treatment of invasive fungal infections. It is semisynthesized from the sulfonated lipohexapeptide FR901379, a nonribosomal peptide pro...

    Authors: Ping Men, Yu Zhou, Li Xie, Xuan Zhang, Wei Zhang, Xuenian Huang and Xuefeng Lu
    Citation: Microbial Cell Factories 2023 22:44
    Content type: Research Published on:

  11. Microbial production of propionic acid (PA) from renewable resources is limited by the slow growth of the producer bacteria and product-mediated inhibition. The present study evaluates high cell density contin...

    Authors: Victor Hugo Cavero-Olguin, Tarek Dishisha and Rajni Hatti-Kaul
    Citation: Microbial Cell Factories 2023 22:43
    Content type: Research Published on:

  12. Adding acid protease to feed can enhance protein digestibility, boost feed utilization, and stimulate the growth of animals in breading industry. In order to obtain an acid protease with high hydrolysis effici...

    Authors: Mengyuan Wei, Pengcheng Chen, Pu Zheng, Xiumei Tao, Xiaowei Yu and Dan Wu
    Citation: Microbial Cell Factories 2023 22:42
    Content type: Research Published on:

  13. Pediocin PA-1 is a bacteriocin of recognized value with applications in food bio-preservation and the medical sector for the prevention of infection. To date, industrial manufacturing of pediocin PA-1 is limit...

    Authors: Jens Christmann, Peng Cao, Judith Becker, Christian K. Desiderato, Oliver Goldbeck, Christian U. Riedel, Michael Kohlstedt and Christoph Wittmann
    Citation: Microbial Cell Factories 2023 22:41
    Content type: Research Published on:

  14. Kojic acid (KA) is a widely used compound in the cosmetic, medical, and food industries, and is typically produced by Aspergillus oryzae. To meet increasing market demand, it is important to optimize KA productio...

    Authors: Liu Wu, Licheng Zhang, Xiaojie Li, Ruitong Lv, Wei Cao, Weixia Gao, Jiao Liu, Zhoujie Xie and Hao Liu
    Citation: Microbial Cell Factories 2023 22:40
    Content type: Research Published on:

  15. Virus-like particles are an interesting vector platform for vaccine development. Particularly, Hepatitis B virus core antigen has been used as a promising VLP platform. It is highly expressed in different reco...

    Authors: Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati and Mohammad Hadi Eskandari
    Citation: Microbial Cell Factories 2023 22:39
    Content type: Research Published on:

  16. Trichoderma reesei (T. reesei) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous proteins, little is known about the molecular mechanisms governing he...

    Authors: Wangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu and Xiaoyun Su
    Citation: Microbial Cell Factories 2023 22:38
    Content type: Research Published on:

  17. Poly-γ-glutamic acid (γ-PGA) is biodegradable, water-soluble, environment-friendly, and edible. Consequently, it has a variety of industrial applications. It is crucial to control production cost and increase ...

    Authors: Lifei Guo, Liang Lu, Huichao Wang, Xiaoxing Zhang, Genan Wang, Tingbin Zhao, Guobao Zheng and Changsheng Qiao
    Citation: Microbial Cell Factories 2023 22:37
    Content type: Research Published on:

  18. Cyanobacteria are prokaryotic organisms with wide morphological and metabolic diversity. By means of photosynthesis, they convert inorganic compounds into biomolecules, which may have commercial interest. In t...

    Authors: Douglas Henrique Baracho and Ana Teresa Lombardi
    Citation: Microbial Cell Factories 2023 22:36
    Content type: Research Published on:

  19. Synechocystis sp. PCC 6803 utilizes pyruvate and glyceraldehyde 3-phosphate via the methylerythritol 4-phosphate (MEP) pathway for the biosynthesis of terpenoids. Considering the deep connection of the MEP pathwa...

    Authors: João S. Rodrigues, Barbara Bourgade, Karen R. Galle and Pia Lindberg
    Citation: Microbial Cell Factories 2023 22:35
    Content type: Research Published on:

  20. Energy is the basis and assurance for a world's stable development; however, as traditional non-renewable energy sources deplete, the development and study of renewable clean energy have emerged. Using microal...

    Authors: Mostafa El-Sheekh, Mostafa Elshobary, Eman Abdullah, Refat Abdel-Basset and Metwally Metwally
    Citation: Microbial Cell Factories 2023 22:34
    Content type: Research Published on:

  21. Existing methods for alkene epoxidation are based on lipase-catalysed perhydrolysis. However, the inactivation of the expensive lipase enzyme is problematic for enzymatic epoxidation at large scales due to the...

    Authors: Lili Xu, Yimin Qin, Yufeng Song, Aixing Tang and Youyan Liu
    Citation: Microbial Cell Factories 2023 22:33
    Content type: Research Published on:

  22. Streoptomyces rimosus M527 is a producer of the polyene macrolide rimocidin which shows activity against various plant pathogenic fungi. Notably, the regulatory mechanisms underlying rimocidin biosynthesis are ye...

    Authors: Huijie Li, Yefeng Hu, Yongyong Zhang, Zheng Ma, Andreas Bechthold and Xiaoping Yu
    Citation: Microbial Cell Factories 2023 22:32
    Content type: Research Published on:

  23. A significant threat to the public's health is the rise in antimicrobial resistance among numerous nosocomial bacterial infections. This may be a detriment to present initiatives to enhance the health of immun...

    Authors: Nessma A. El-Zawawy, Sameh Samir Ali and Hoda S. Nouh
    Citation: Microbial Cell Factories 2023 22:31
    Content type: Research Published on:

  24. Given the crucial role of gut microbiota in animal and human health, studies on modulating the intestinal microbiome for therapeutic purposes have grasped a significant attention, of which the role of fecal mi...

    Authors: Yaping Wang, Yuanyuan He, Ying Liang, Han Liu, Xiushuang Chen, Muhammad Fakhar-e-Alam Kulyar, Asim Shahzad, Kunhua Wei and Kun Li
    Citation: Microbial Cell Factories 2023 22:30
    Content type: Research Published on:

  25. The disposal of plastic waste is a major environmental challenge. With recent advances in microbial genetic and metabolic engineering technologies, microbial polyhydroxyalkanoates (PHAs) are being used as next...

    Authors: Sung Sun Yim, Jae Woong Choi, Yong Jae Lee and Ki Jun Jeong
    Citation: Microbial Cell Factories 2023 22:29
    Content type: Research Published on:

  26. A system for itaconic acid synthesis from cellulose by Neurospora crassa was established, resulting in the highest yield of itaconic acid was 354.08 + 35.99 mg/L. Meanwhile, cellulase activity increased significa...

    Authors: Jiajia Zhao, Caihong Ma, Yaojie Mei, Jingjing Han and Chen Zhao
    Citation: Microbial Cell Factories 2023 22:28
    Content type: Research Published on:

  27. The goal of this study was to create a multi-strain probiotic gel that would foster a lactobacilli-dominated vaginal microbiota in pregnant women and ensure appropriate eubiosis for the newborn. Nomadic lactob...

    Authors: Claudia Cappello, Marta Acin-Albiac, Daniela Pinto, Andrea Polo, Pasquale Filannino, Fabio Rinaldi, Marco Gobbetti and Raffaella Di Cagno
    Citation: Microbial Cell Factories 2023 22:27
    Content type: Research Published on:

  28. Vitamin B12 is a widely used compound in the feed and food, healthcare and medical industries that can only be produced by fermentation because of the complexity of its chemical synthesis. Besides, the use of Gen...

    Authors: Álvaro Calvillo, Teresa Pellicer, Marc Carnicer and Antoni Planas
    Citation: Microbial Cell Factories 2023 22:26
    Content type: Research Published on:

  29. Sustainable production of triglycerides for various applications is a major focus of microbial factories. Oleaginous yeast species have been targeted for commercial production of microbial oils. Among all the ...

    Authors: Pariya Shaigani, Tobias Fuchs, Petra Graban, Sophia Prem, Martina Haack, Mahmoud Masri, Norbert Mehlmer and Thomas Brueck
    Citation: Microbial Cell Factories 2023 22:25
    Content type: Research Published on:

  30. Bacterial Cellulose (BC) is still the most renewable available biopolymer produced in fine nature from alternative microbial sources as bacteria. In the present study, newly BC producing bacteria were successf...

    Authors: Mohamed S. Hasanin, Mohamed Abdelraof, Amr H. Hashem and Houssni El Saied
    Citation: Microbial Cell Factories 2023 22:24
    Content type: Research Published on:

  31. Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures. CYP719As could catalyze the ...

    Authors: Xiuyu Liu, Xiang Jiao, Yatian Cheng, Ying Ma, Junling Bu, Baolong Jin, Qishuang Li, Zhimin Hu, Jinfu Tang, Changjiangsheng Lai, Jian Wang, Guanghong Cui, Yun Chen, Juan Guo and Luqi Huang
    Citation: Microbial Cell Factories 2023 22:23
    Content type: Research Published on:

  32. Pseudomonas putida DOT-T1E is a highly solvent tolerant strain for which many genetic tools have been developed. The strain represents a promising candidate host for the synthesis of aromatic compounds—opening a ...

    Authors: Ana García-Franco, Patricia Godoy, Estrella Duque and Juan Luis Ramos
    Citation: Microbial Cell Factories 2023 22:22
    Content type: Research Published on:

  33. Despite recent advances in genetic engineering tools for effectively regulating and manipulating genes, efficient simultaneous multigene insertion methods have not been established in Bacillus subtilis. To date, ...

    Authors: Jordi Ferrando, Oriana Filluelo, Daniel R. Zeigler and Pere Picart
    Citation: Microbial Cell Factories 2023 22:21
    Content type: Research Published on:

  35. 4-Androstene-3,17-dione (4-AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (BA) are the most important and representative C19- and C22-steroidal materials. The optimalization of sterol production with mycobact...

    Authors: Shikui Song, Jianxin He, Meng Gao, Yongqi Huang, Xiyao Cheng and Zhengding Su
    Citation: Microbial Cell Factories 2023 22:19
    Content type: Research Published on:

  36. Although Levan-type fructooligosaccharides (L-FOS) have been shown to exhibit prebiotic properties, no efficient methods for their large-scale production have been proposed. One alternative relies on the simul...

    Authors: Ángela Ávila-Fernández, Silvia Montiel, María Elena Rodríguez-Alegría, Luis Caspeta and Agustín López Munguía
    Citation: Microbial Cell Factories 2023 22:18
    Content type: Research Published on:

  37. The tobacco leaf–derived cembratriene-ol exhibits anti-insect effects, but its content in plants is scarce. Cembratriene-ol is difficult and inefficiently chemically synthesised due to its complex structure. M...

    Authors: Haiquan Yang, Kunjie Zhang, Wei Shen, Lei Chen, Yuanyuan Xia, Wei Zou, Yu Cao and Xianzhong Chen
    Citation: Microbial Cell Factories 2023 22:17
    Content type: Research Published on:

  38. The large application potential of microbiomes has led to a great need for mixed culture methods. However, microbial interactions can compromise the maintenance of biodiversity during cultivation in a reactor....

    Authors: Alexis Dijamentiuk, Cécile Mangavel, Annelore Elfassy, Florentin Michaux, Jennifer Burgain, Emmanuel Rondags, Stéphane Delaunay, Sandie Ferrigno, Anne-Marie Revol-Junelles and Frédéric Borges
    Citation: Microbial Cell Factories 2023 22:16
    Content type: Research Published on:

  39. Spinosad is a macrolide insecticide with the tetracyclic lactone backbone to which forosamine and tri-o-methylrhamnose are attached. Both the sugar moieties are essential for its insecticidal activity. In biosynt...

    Authors: Xiaochen Li, Ruofei Guo, Ji Luan, Jun Fu, Youming Zhang and Hailong Wang
    Citation: Microbial Cell Factories 2023 22:15
    Content type: Research Published on:

  40. Pseudomonas putida has received increasing interest as a cell factory due to its remarkable features such as fast growth, a versatile and robust metabolism, an extensive genetic toolbox and its high tolerance to ...

    Authors: Lyon Bruinsma, Maria Martin-Pascual, Kesi Kurnia, Marieken Tack, Simon Hendriks, Richard van Kranenburg and Vitor A. P. Martins dos Santos
    Citation: Microbial Cell Factories 2023 22:14
    Content type: Research Published on:

  41. Gene expression data of cell cultures is commonly measured in biological and medical studies to understand cellular decision-making in various conditions. Metabolism, affected but not solely determined by the ...

    Authors: Haoyang Yao, Sanjeev Dahal and Laurence Yang
    Citation: Microbial Cell Factories 2023 22:13
    Content type: Research Published on:

  42. Microalgae are considered a suitable production platform for high-value lipids and oleochemicals. Several species including Nannochloropsis oceanica produce large amounts of essential ...

    Authors: Christian Südfeld, Aamna Kiyani, Katrin Wefelmeier, René H. Wijffels, Maria J. Barbosa and Sarah D’Adamo
    Citation: Microbial Cell Factories 2023 22:12
    Content type: Research Published on:

  44. L-cysteine is an essential chemical building block in the pharmaceutical-, cosmetic-, food and agricultural sector. Conventionally, L-cysteine production relies on the conversion of keratinous biomass mediated...

    Authors: Kevin Heieck, Nathanael David Arnold and Thomas Bartholomäus Brück
    Citation: Microbial Cell Factories 2023 22:10
    Content type: Research Published on:

  45. A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance. Cryptdins (Crps) are...

    Authors: Yuchi Song, Yi Wang, Shaonan Yan, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe and Tomoyasu Aizawa
    Citation: Microbial Cell Factories 2023 22:9
    Content type: Research Published on:

  46. Purification of L-methionine γ-lyase (MGL) from A. fumigatus was sequentially conducted using heat treatment and gel filtration, resulting in 3.04 of purification fold and 73.9% of enzymatic recovery. The molecul...

    Authors: Mahmoud H. Hendy, Amr H. Hashem, Waleed B. Suleiman, Mahmoud H. Sultan and Mohamed Abdelraof
    Citation: Microbial Cell Factories 2023 22:8
    Content type: Research Published on:

    The Correction to this article has been published in Microbial Cell Factories 2023 22:58

  47. The oleaginous yeast Yarrowia lipolytica is increasingly used as a chassis strain for generating bioproducts. Several hybrid promoters with different strengths have been developed by combining multiple copies of ...

    Authors: Lea Vidal, Esteban Lebrun, Young-Kyoung Park, Guillaume Mottet and Jean-Marc Nicaud
    Citation: Microbial Cell Factories 2023 22:7
    Content type: Research Published on:

  48. Phaeodactylum tricornutum (Pt) is a critical microbial cell factory to produce a wide spectrum of marketable products including recombinant biopharmaceutical N-glycoproteins. N-glycosylation modification of prote...

    Authors: Xihui Xie, Jianchao Yang, Hong Du, Jichen Chen, Edmond Sanganyado, Yangmin Gong, Hua Du, Weizhou Chen, Zhengyi Liu and Xiaojuan Liu
    Citation: Microbial Cell Factories 2023 22:6
    Content type: Research Published on:

  49. New antibiotics are urgently needed in clinical treatment of superdrug-resistant bacteria. Nonribosomal peptides (NRPs) are a major source of antibiotics because they exhibit structural diversity, and unique a...

    Authors: Kan Jiang, Ximing Chen, Wei Zhang, Yehong Guo and Guangxiu Liu
    Citation: Microbial Cell Factories 2023 22:5
    Content type: Research Published on:

  50. The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production, however, the loss of camptothecin productivity by fungi with the stor...

    Authors: Ashraf S. A. El-Sayed, Nelly M. George, Amira Abou-Elnour, Rasha M. El-Mekkawy and Marwa M. El-Demerdash
    Citation: Microbial Cell Factories 2023 22:4
    Content type: Research Published on:
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Companion Journals

Microbial Cell Factories is a companion journal to:

Biotechnology for Biofuels and Bioproducts

Biotechnology for the Environment

Blue Biotechnology

Biotechnology for Sustainable Materials

Fungal Biology and Biotechnology


Microbial Cell Factories

ISSN: 1475-2859

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